Global solutions lawrence berkeley national laboratory. Lawrence berkeley national laboratorys science is a global enterprise. Here we report the complete biosynthesis of the major cannabinoids cannabigerolic acid. Extremescale scientific software development kit for the exascale computing project.
Keasling, associate director at the national lab, ceo at jbei and uc berkeley professor, says that synthetic biology is not so much a new field as it is an advance on genetic engineering, which has been around since the 1970s. The research team out of the keasling lab, led by campus professor and senior faculty scientist at lawrence berkeley national laboratory jay keasling, successfully synthesized both naturally. Jay, is a preeminent scientist in the field of synthetic biology. Keasling wins 2012 international metabolic engineering award. Uc berkeley press release university of california, berkeley.
A team of researchers led by jay keasling at the joint bioenergy institute jbei has developed a process for the enzymatic activation and cyclization of hydroxyl fatty acids for the production of alkyl lactones in engineered recombinant host cells. All materials received in central receiving are processed into the iboxtrackit package tracking software. Keasling, professor of chemical and biomolecular engineering and of bioengineering at the university of california, berkeley, and faculty senior scientist at lawrence berkeley national laboratory, has been selected by the american institute of. Bioengineering professor jay keasling has been appointed the new director of the physical biosciences division at lawrence berkeley lab. Since your browser does not support javascript, you must press the continue button once to proceed.
Berkeley lab researchers are part of a collaboration that will use the nations first exascale computer to search for new, more efficient photovoltaic solar cell materials. Or, use the form to the right to search the titles in this index by keyword. Ashland lectureship, university of kentucky 2009 danckwerts lectureship, world congress on chemical engineering 2009 inaugural biotech humanitarian award, biotechnology industry organization bio 2009 2009 university lectures in chemistry, department of chemistry, boston college. The research in the keasling laboratory focuses on the metabolic engineering of microorganisms for the environmentally friendly. From the labs site in the hills overlooking the university of california berkeley campus, to locations across the continent and around the world, berkeley lab scientists are working at the frontiers of knowledge to better understand our universe and to address the challenges facing our nation and our planet. The technology transfer process technology transfer is a superb opportunity to demonstrate the value of our discoveries and to benefit. These tools include programmable genetic control elements, dna design and assembly methods, and engineered enzymes to synthesize unnatural chemicals. Many of these are available to the public free of charge. If you identify any major omissions or other inaccuracies in the publication list, please let us know. Switchable ionic liquids based on dicarboxylic acids for onepot conversion of biomass to an advanced biofuel.
Jay keasling is one of the foremost authorities in the field of synthetic biology. California bioresources economy summit agenda california air. Jay keasling heads berkeley labs new synthetic biology department, the first of its kind in the world. Yasuo yoshikuni synthetic biologypathway engineering doe. Berkeley lab breaks ground on integrative genomics building. Web login service loading session information loading login session information from the browser. Lawrence berkeley national laboratory lignin somerville as interim. Jay keasling hits jackpot with biofuel startup sfgate. Gtl researchers at lawrence berkeley national laboratory. In the keasling lab, part of our effort focuses on understanding the fundamental biochemical processes that govern the enzymatic catalysis of pks and nrps products. Technology transfer involves moving an invention or. Reference gallery download www home webmaster building technology and urban systems department eetd berkeleylab webmaster building. Joint bioenergy institute jbei researchers led by jay keasling have invented a technology to produce fatty alcohols from engineered yeast cells.
He is the director of the synthetic biology engineering research center synberc, associate laboratory director for biosciences at the lawrence berkeley national laboratory. Sbi and berkeley lab scientist nathan hillson and two partners aim to make genetic engineering cheaper and faster through a startup that is building on j5 software for dna construction. Jay keasling chief executive officer joint bioenergy. During the tour of the advanced light source, the governor met with uc berkeley professors paul alivisatos and jay keasling, both of whom hold joint appointments at the lab. Jbei promotes interest in science through educational outreach programs with students and the general public. Biotechnology at the cutting edge keasling youtube. If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. The scientific and engineering community at uc berkeley and its nearby research centers is a global leader in synthetic biology research. See the complete profile on linkedin and discover jay.
Uc berkeley professor jay keasling leaned forward in his armchair at the joint bioenergy institute, where he leads 200 researchers on a quest to coax yeast cells into producing fuels that provide the same energy, with less pollution, as petroleum. College faculty have been leaders at the frontiers of knowledge since 1872. Joining this years class of 68 new members and nine foreign associates were lisa alvarezcohen, eugene haller, jay keasling, art rosenfeld and xiang zhang. Jay keasling at the berkeley repertory theater lbl jbei. Jan 31, 2017 extending the roots of team science at its birthplace, berkeley lab will soon bring together researchers from the doe joint genome institute with those from the systems biology knowledgebase kbase under one roof. Some software may not have details explanation or their price, program version updated. Lawrence berkeley national laboratory lbnl federal labs. The groundbreaking for the integrative genomics building igb today celebrates the future colocation of two partnering scientific user community resources and launches construction. Csto for biosciences and faculty senior scientist, lbnl dr. Software must be formally reported before you distribute it to anyone outside of lbnl or doe, even if distributed for free. Keasling to receive aiches doing a world of good medal at. Distinguished professor of biochemical engineering has won the 2012 international metabolic engineering award. All software information on this site, is solely based on what our users submit. Jay keasling is a pioneer in engineering microbes and metabolism.
Jay keasling, pbd division director and inventor, on finding a way to produce an affordable antimalaria drug over 55,000 copies of berkeley lab software were downloaded last year. The keasling lab at the university of california, berkeley and lawrence berkeley national laboratory is an interdisciplinary team of scientists and engineers. It employs advanced monte carlo raytracing with optimizations for complex building geometries and fenestration systems. Jay keasling awarded doing a world of good medal college. The lab receiving the grant, called jbei joint bioenergy institute, is a collaboration between berkeley, uc davis, stanford, lbnl, lawrence livermore, and sandia national lab. Lbl jbei director jay keasling giving presentation to community of berkeley on biofuels. Renewable energy from synthetic biology lbnl science at. Modeling of microbial metabolism is a topic of growing importance in biotechnology. The groundbreaking for the integrative genomics building igb on january 31, 2017, at the former site of a. Synthetic biology works because biological creatures are, in essence, programmable manufacturing systems.
Keasling subsequently founded an emeryville, california, company, demetrix inc. It packs lots of energy for its volume, and its stable, transportable, and noncorrosive. Corinne scown lawrence berkeley national laboratory. Lawrence berkeley national laboratory news center berkeley lab, a department of energy doe office of science lab managed by university of california. Synthetic biology research at the heart of controversy. Engineering cellular metabolism journal article osti. This unique basic research program could help transform lignin into a. Here, we employ crisprcas9 technology to build a cloningfree toolkit that addresses commonly encountered obstacles in metabolic engineering, including chromosomal integration locus and promoter selection, as well as protein localization and. Jay keasling lawrence berkeley national laboratory. Rationally designed synthetic transcription factors eib3211. Lawrence berkeley natl lab roy kaltschmidt, photographer xbd2007060017424.
Berkeley lab window provides a versatile heat transfer analysis method consistent with the updated rating procedure developed by. Jay keasling, a professor in the departments of bioengineering and of chemical and biomolecular engineering at uc berkeley who also holds a senior faculty scientist position at berkeley lab, led a team that genetically modified brewers yeast saccharomyces cerevisiae to produce cannabinoids via biosynthesis. More sbis jay keasling wins heinz award san francisco chronicle 9. Apr 07, 2020 preparing photovoltaic research for exascale. Please visit for our current information this work was supported by the assistant secretary for energy efficiency and renewable energy, office of building technology, state and community programs of the u. Lawrence berkeley national laboratory berkeley lab has been a leader in science and engineering research for more than 70 years. Despite the extensive use of saccharomyces cerevisiae as a platform for synthetic biology, strain engineering remains slow and laborious. Unique isoprenoidlike compounds carbon numbers not in. Through its varied programs, aiche continues to be a focal point for.
Aercalc is used to calculate the annual energy performance of window attachments. Liszka, michael j, aram kang, nvsn m konda, kim tran, john m gladden, seema singh, jay d keasling, corinne scown, taek soon lee, blake a simmons, and kenneth l sale. The windows and daylighting group at lawrence berkeley national laboratory lbnl has developed a variety of software tools for analyzing energy performance of windows. Doe renews funding for joint bioenergy institute at. Distinguished professor of biochemical engineering at the university of californiaberkeley. Dear berkeley lab colleagues, i am excited to announce new roles for two of our leaders of the biosciences area. Berkeley lab window is a publicly available computer program for calculating total window thermal performance indices i. For the consumer, the benefits are highquality, lowcost cbd and thc.
Window optics lawrence berkeley national laboratory. Go to and enter tracking information what does receiving do. Current pioneering research includes premier programs in catalysis, thermodynamics, chemical biology, atmospheric chemistry, the development of polymer, optical and semiconductor materials, and nanoscience, among others. Startup u california magazine cal alumni association. Chief executive officer and director of new pathways and metabolic models. Use ds the directory of both people and organizations. Jay keasling, berkeley labs associate laboratory director for biosciences, ceo of the joint bioenergy institute and uc berkeleys hubbard howe jr.
A software abstract and disclosure should be submitted a few months before completion of the software or as soon thereafter as possible. Laboratory director steve chu made the announcement this morning that dr. Chief executive officer, joint bioenergy institute. Jay keasling, associate laboratory director, lawrence berkeley national laboratory. Jbei is a partnership led by lawrence berkeley national laboratory lbnl that. Ktvu channel 2 health and science editor john fowler will moderate a panel of lawrence berkeley national laboratory scientists who are developing ways to convert the solar energy stored in plants into liquid fuels. Renewables portfolio standards resources electricity. The keasling lab has focused on the development of basic synthetic biology tools to make it easier to design, construct and control metabolism inside cells. Directors message on biosciences leadership transition. Nsf grant to launch worlds first opensource genetic parts. Blueprint for new cal bioscience institute plant researcher from stanford likely to be director.
Radiance www server lawrence berkeley national laboratory. Software window optics lawrence berkeley national laboratory. The selection of jbei is a major vote of confidence in the bay areas growing leadership in the national effort to develop new and cleaner sources of renewable energy, said jay keasling, uc berkeley professor of chemical engineering and jbeis chief executive officer. Berkeley lab tracks and analyzes state renewables portfolio standards rps, in order to inform policymakers, program administrators, and others about the design and impacts of these policies. The keasling lab at the university of california, berkeley and lawrence berkeley national laboratory is an interdisciplinary team of scientists and engineers who focus on engineering the chemistry inside microbial cells to produce lifesaving therapies, cleanburning fuels, and new materials for a. Jan 20, 2010 with seed money from the national science foundation nsf, bioengineers from the university of california, berkeley, and stanford university are ramping up efforts to characterize the thousands of control elements critical to the engineering of microbes so that eventually, researchers can mix and match these dna parts in synthetic organisms to produce new drugs, fuels or chemicals. Complete biosynthesis of cannabinoids and their unnatural. Keasling succeeds graham fleming, who founded the division in 1997. The keasling lab at the university of california, berkeley and lawrence berkeley national laboratory is an interdisciplinary team of scientists and engineers who focus on engineering the chemistry inside microbial cells to produce lifesaving therapies, cleanburning fuels, and new materials for a variety of applications.
Jay keasling, uc berkeley connie lee, ucsf center for systems. Professors innovations benefit society, economy berkeley news. Keasling chief executive officer, joint bioenergy institute senior faculty scientist. Using the most current advances in multiomic, dna recombination and biochemical technologies, we aim at understanding the basic mechanistic foundation of pks and nrps biocatalysis. Come work at berkeley labs earth and environmental sciences area. Staff scientist, lawrence berkeley national laboratory. By genetically modifying the yeast cells, researchers were able to produce high levels of longchain alcohols in the 1218 carbon range containing terminal alcohol groups. Jay keasling, ceo of joint bioenergy institute jbei credit. Enzymatic activation and cyclization of hydroxy fatty acids. Pdf chemoinformaticguided engineering of polyketide. The dna instruction manual buried inside every cell its software, in a sense can be replaced with a manmade version, giving us the ability to tell it what to make. Mathematical modeling helps provide a mechanistic understanding for the studied process, separating the main drivers from the circumstantial ones, bounding the outcomes of experiments and guiding engineering approaches. The adios framework for scientific data on exascale systems, john wu, leader of the scientific data management group in crd, is a member of the team.
Alivisatos, who is associate laboratory director for physical sciences, described how he uses the light energy in the als to study the structural properties of nanocrystals. Uvalues, solar heat gain coefficients, shading coefficients, and visible transmittances. Jay keasling is the chief executive officer of jbei, the associate laboratory director for biological sciences at lawrence berkeley national laboratory, and the hubbard howe jr. Click on a letter above to see an alphabetized list of items. Keasling, professor, university of california, berkeley and senior faculty scientist, lawrence berkeley national laboratory. Highlevel production of fatty alcohols from engineered. Distinguished professor of biochemical engineering at uc berkeley, where he holds appointments in bioengineering and in. Lawrence berkeley national laboratory berkeley lab is a department of energy doe office of science lab managed by university of california. Keasling also is director of lbnl s physical biosciences division. This index page includes links to websites throughout berkeley lab.
Distinguished professor of biochemical engineering, acting deputy director of lawrence berkeley national laboratory, director of the physical biosciences division of lbnl and of synberc, and ceo of the joint bioenergy institute jbei. We are testing a new system for linking publications to authors. A joint bioenergy institute jbei research team led by jay keasling has invented a method to produce a terpene product with a carbon number that is not a multiple of five, yielding fuellike molecules with different physical properties such as energy density, flash point, viscosity, melting temperature, and water retention than the 5, 10, and 15carbon isoprenoids under exploration as fuels. Laboratory director steve chu is pleased to announce jay keasling as the new division director for physical biosciences. Highlevel production of fatty alcohols from engineered yeast. Olga diaz executive assistant lawrence berkeley national. James spaeth, program manager, us doe bioenergy technologies office. So hes going to get microbes to make something better there are good reasons gasoline has been king of the road for more than a century. In the feature entitled the scientist still fighting for the clean fuel the world forgot, keasling discusses the progress made in the quest for affordable advanced biofuels. In helios, he directs the biology program, incorporating a range of approaches to increasing the efficacy and economy of plants and cellulosedegrading microbes to make solarbased fuels. Radiance is a suite of programs for the analysis and visualization of lighting in design.
Jay keasling, berkeley lab ald for biosciences and ceo of the joint bioenergy institute, appears in a video on biotechnology at the smithsonians. In addition to denby, li, costello, keasling, donaldson and bamforth, other coauthors are van vu of uc berkeley, weiyin lin, leanne jade chan, christopher petzold, henrik scheller and hector garcia martin of the joint bioenergy institute in emeryville, which is part of lawrence berkeley national laboratory, and joseph williams of uc davis. Five researchers affiliated with berkeley lab have been elected into the national academy of engineering nae, one of the highest professional honors accorded to an engineer. Jay keasling profile jay keasling believes ethanol is a poor biofuel. Extending the roots of team science at its birthplace, lawrence berkeley national laboratory berkeley lab will soon bring together researchers from the department of energy doe joint genome institute with those from the systems biology knowledgebase kbase under one roof.
During the early 2000s, jay led a uc berkeley research team to use engineered yeast to synthetically produce artemisinin, the powerful antimalarial drug. Five berkeley lab researchers elected to nae berkeley lab. To see these changes, it is recommended that you uninstall the original cgdb v 16 and then reinstall this latest version. Sbi builds on this strong foundation by providing new opportunities for collaboration and education, as well as a common technology infrastructure. For graduate students at uc berkeley or ucsf interested in rotating in the keasling lab please contact dr. Jul 09, 2015 a basic discovery in the lab of chemical engineer jay keasling led to a collaboration with keaslings startup, amyris biotechnologies, and the institute for one world health iowh to develop for use in developing countries an inexpensive drug to battle malaria, which kills nearly 1 million people a year, most of them children. Jun 25, 20 this site is an archive of discontinued pages.
Jan 20, 2010 bioengineers from the uc berkeley and stanford university are ramping up efforts to characterize the thousands of control elements critical to the engineering of microbes so that eventually, researchers can mix and match these dna parts in synthetic organisms to produce new drugs, fuels or chemicals. The main goal of the lbnl integrated biological imaging center is to integrate the amazing breadth of imaging expertise and technology currently at the lab to take better advantage of our capabilities and to address some of the current limitations in performing integrated imaging, analysis and visualization. Roy kaltschmidtberkeley lab jbei has established a strong track record of producing technologies that make biofuels research easier and that help transform the u. Rationally designed synthetic transcription factors eib. View jay keasling s profile on linkedin, the worlds largest professional community. Jay keasling s yeastmade synthetic artemisinin is being shipping to africa to eradicate malaria and uc berkeley reflects on another great year. Jay keasling is the philomathia professor of alternative energy at the university of california, berkeley in the departments of bioengineering and chemical and biomolecular engineering, senior faculty scientist at lawrence berkeley national laboratory, and chief executive officer of. Lawrence berkeley national laboratory lbnl investigators aindrila mukhopadhyay, adam arkin, and jay keasling, together with coinvestigators on the lbnl virtual institute of microbial stress and survival vimss project, discover key clues to how the microbe desulfovibrio vulgaris hildenborough adapts its physiology to enable survival in.
Jay keasling has agreed to take on an important new role as chief science and technology officer for biosciences, and mary maxon has accepted my offer to replace jay as associate laboratory director for biosciences. Located on a 200acre site in the hills above the university of californias berkeley campus, adjacent to the san francisco bay, berkeley lab holds the distinction of being the oldest of the u. Berkeley labs earth and environmental sciences area eesa is at the crossroads of facing todays challenges in creating a secure earth environment by pushing beyond the fundamental and applied sciences and developing technology and tools applicable for future research. Alternative fuels, like ethanol, have a hard act to follow. Jay keasling, coleader of berkeley labs helios project, is a groundbreaking researcher in the new scientific field of synthetic biology. Jay keaslings laboratory at the university of california, berkeley has engineered both escherichia coli and saccharomyces cerevisiae to produce artemisinic acid, a precursor to artemisinin that can be derivatized using established, simple, inexpensive chemistry to form artemisinin or any artemisinin derivative currently used to treat malaria. Aiche has announced the 2019 doing a world of good medal will be presented to jay d. Jay keasling is the chief executive officer of jbei, the associate laboratory director for. It will be headquartered somewhere around emeryville and run by jay keasling, the berkeley scientist who pioneered synthetic biology. Evolutionary biology and is on the scientific advisory board of clc bio and the board of directors of the evolutionary software foundation. Keasling 21 december 2017 page 3 2009 cox distinguished lectureship, washington university, 2009.
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